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Motor proteins 1: kinesins
1Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235, USA.
Protein Profile
|January 1, 1995
Summary
Kinesins and related proteins are rapidly advancing, with increasing detail on their functions and properties. This review synthesizes current knowledge on these crucial motor proteins.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Kinesin research is accelerating, with detailed exploration of kinesin's in vivo functions and properties.
- The kinesin superfamily now includes dozens of related proteins, with functional knowledge rapidly increasing.
- Detailed structural information is emerging for kinesin-related proteins, such as ncd, surpassing that of kinesin heavy chain.
Purpose of the Study:
- To provide a comprehensive review of major published works on kinesin and kinesin-related proteins.
- To complement existing reviews and books focusing on specific aspects of the kinesin family or MT motor proteins.
- To establish a foundation for planned annual updates on kinesin research.
Main Methods:
- Comprehensive literature review of published works on kinesins.
- Synthesis of data on in vivo functions, biophysical, and enzymatic properties.
- Analysis of primary structure and functional data for kinesin-related proteins.
Main Results:
- Significant progress in understanding kinesin and kinesin-related proteins.
- Expanding knowledge of their structures, functions, and properties.
- Identification of numerous kinesin-related proteins with ongoing research into their roles.
Conclusions:
- Kinesin research is a rapidly advancing field with significant ongoing discoveries.
- This review consolidates current knowledge and highlights the expanding understanding of kinesin functions and structures.
- Future annual updates will track the continued progress in this dynamic area of molecular motor research.