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Determination of glomerular filtration rate with radionuclide renography and direct urinary activity quantitation
A C Otto1, P H Pretorius, M Dunn
1Department of Nuclear Medicine, University of the Orange Free State, Bloemfontein.
Objective:
The direct urinary activity quantitation method is quick (approximately 40 minutes), requires only a single blood sample, is performed as part of standard renal scanning and shows high accuracy compared with 24-hour creatinine clearance. The purpose was to evaluate the practical application and accuracy of this technique at our clinic.
Design:
Direct urinary activity quantitation was done in patients scheduled for routine radionuclide renography and compared to standard multiple-blood-sample techniques by means of Cr-51-EDTA and Tc-99m-DTPA.
Setting:
Academic Medical Complex, Department of Nuclear Medicine, Universitas Hospital, Bloemfontein.
Participants:
Fifteen patients scheduled for routine radionuclide renography (glomerular filtration rate (GFR) determination) were voluntarily enrolled in the study. The GFRs of selected patients varied over a wide range. Possible obstructive uropathy was excluded.
Main Outcome Measures:
GFRs obtained by the direct urinary method were compared with GFRs determined by multisample Cr-51-EDTA and Tc-99m DTPA.
Results:
GFRs from the direct urinary method compared with multisample Tc-99m-DTPA showed differences from -19.85 to 22.95 ml/min with a mean of 0.2 (+/- 12.25) ml/min (r = 0.93). When compared with multisample Cr-51 EDTA, differences ranged from -34.35 to 21.05 ml/min with a mean of -4.25 (+/- 16.08) ml/min (r = 0.90).
Conclusion:
The direct urinary activity technique is
Conclusion:
The direct urinary activity technique is easily applied and highly accurate compared with previous standardised multisample radionuclide techniques for determination of GFR.