Related Experiment Videos
Stevens-Johnson syndrome resulting from whole-brain radiation and phenytoin
G H Cockey1, S T Amann, S B Reents
1College of Medicine, University of Florida, Gainesville, USA.
American Journal of Clinical Oncology
|February 1, 1996
Abstract:
Phenytoin, one of the most widely prescribed anticonvulsants, and steroids are routinely utilized for seizure prophylaxis in patients with various intracranial tumors. We report a case of severe Stevens-Johnson syndrome (SJS), documented by biopsy, which occurred in a patient, with metastatic squamous cell carcinoma receiving phenytoin, whole-brain radiation therapy (WBRT), and a tapering steroid dose. The pathogenesis and implications are then briefly discussed.