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[Parkinsonism induced by sodium valproate]

M A del Real Francia1, J Sanz Martínez, J Vaamonde Gamo

  • 1Servicio de Neurología, Complejo Hospitalario de Ciudad Real.

Neurologia (Barcelona, Spain)
|November 1, 1995
PubMed
Summary

Parkinsonism, a rare side effect of sodium valproate treatment, was observed in two elderly women. Symptoms resolved after discontinuing valproate, suggesting a link between this medication and motor control.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Sodium valproate is an anticonvulsant and mood-stabilizing medication.
  • Parkinsonism is a neurological disorder characterized by tremors, rigidity, and slow movement.

Observation:

  • Two elderly women developed parkinsonian syndrome after several years of sodium valproate therapy.
  • The parkinsonian symptoms in both patients resolved upon withdrawal of sodium valproate.

Findings:

  • Sodium valproate can induce parkinsonism as a rare adverse effect.
  • The reversibility of symptoms upon drug discontinuation supports a causal relationship.

Implications:

  • These cases highlight the importance of considering drug-induced parkinsonism in patients on sodium valproate.

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  • The findings may contribute to understanding the role of GABAergic modulation in motor control.