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Cancer marker assessment: case report on salivary and urinary CEA
F Halberg1, E Haus, D J Lakatua
1Chronobiology Laboratories, University of Minnesota, Minneapolis 55455, USA.
In Vivo (Athens, Greece)
|July 1, 1995
Summary
This study reveals a daily rhythm in salivary Carcinoembryonic antigen (CEA) in a healthy individual, with potential applications for cancer detection and treatment timing.
Area of Science:
- Chronobiology
- Biomarker Research
- Oncology
Background:
- Circadian rhythms influence physiological processes.
- Carcinoembryonic antigen (CEA) is a tumor marker with potential clinical applications.
- Understanding temporal patterns of biomarkers is crucial for disease monitoring.
Observation:
- A healthy individual exhibited a circadian rhythm in salivary CEA.
- The acrophase for salivary CEA was observed around 07:00.
- A borderline significant circadian rhythm was also noted for urinary CEA excretion, with an acrophase around 15:00.
Findings:
- Salivary CEA demonstrates a clear circadian rhythm in healthy individuals.
- Urinary CEA excretion also shows a rhythm, distinct from salivary patterns.
- These rhythms may differ from those observed in colon cancer patients.
Implications:
- Circadian rhythm characteristics of CEA could aid in treatment timing.
- Monitoring CEA rhythms may help detect early chronome alterations related to cancer risk.
- Temporal biomarker analysis offers potential for predisease detection and risk assessment.