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Characterization and work optimization of skeletal muscle as a VAD power source
1Department of Cardiac Surgery, California Pacific Medical Center Research Institute, San Francisco, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1994
Summary
This study developed a mathematical model for skeletal muscle mechanics to power ventricular assist devices (VADs). The model optimizes muscle contraction for efficient VAD coupling, improving device performance.
Area of Science:
- Biomedical Engineering
- Skeletal Muscle Physiology
Background:
- Ventricular assist devices (VADs) require efficient power sources.
- Skeletal muscle offers potential for VAD power but requires understanding of its mechanics.
Purpose of the Study:
- To develop a mathematical model of skeletal muscle mechanics for VAD power applications.
- To investigate optimal coupling between skeletal muscle and a hydraulically actuated VAD.
Main Methods:
- Developed a mathematical model based on the Hill equation.
- Determined model parameters from in vivo isometric and isotonic measurements of pig latissimus dorsi.
- Optimized the model computationally to predict performance.
Main Results:
- Characterized exponential passive force-length relationship and active isometric forces.
- Determined maximum shortening velocity of 85 cm/sec.
- Predicted nonlinear relationships between contraction duration, work output, and muscle force.
Conclusions:
- The model clarifies VAD system design for optimal muscle coupling.
- Operating at maximum instantaneous power does not optimize stroke work for VADs.
- Mathematical modeling is crucial for efficient skeletal muscle-VAD integration.