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The determination of palladium in fosinopril sodium (monopril) by ICP-MS
N Lewen1, M Schenkenberger, T Larkin
1Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903, USA.
Journal of Pharmaceutical and Biomedical Analysis
|June 1, 1995
Abstract:
A rapid, sensitive ICP-MS method was developed to determine palladium in fosinopril sodium. The assay could not be carried out in a purely aqueous solvent owing to the instability of the palladium species in this media. It was found that the most appropriate vehicle for solubilization of this material was a solution of 25% (v/v) 2-butoxyethanol and water. A minimum quantifiable limit of 0.1 microns g-1 for Pd in the sample (corresponding to 1 ng Pd mL-1 in the analyte solution) was obtained.