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Related Experiment Videos

Thermogenesis during rest and exercise in cold air

V J Paolone1, A M Paolone

  • 1Department of Physical Education, Springfield College, MA 01109, USA.

Canadian Journal of Physiology and Pharmacology
|August 1, 1995
PubMed
Summary

Nonshivering thermogenesis contributes to metabolic heat production in acute cold exposure. Blocking this process with propranolol reduced heat production during rest and exercise in cold environments.

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Area of Science:

  • Human Physiology
  • Environmental Medicine
  • Thermoregulation

Background:

  • Nonshivering thermogenesis is a key mechanism for metabolic heat production in response to cold.
  • Understanding the contribution of nonshivering thermogenesis to acute cold exposure is crucial for human adaptation and performance.

Purpose of the Study:

  • To investigate the role of nonshivering thermogenesis in metabolic heat production during rest and exercise in a cold environment.
  • To determine if propranolol can effectively block nonshivering thermogenesis and its impact on thermoregulation.

Main Methods:

  • Nine non-cold-acclimated subjects (5 female, 4 male) underwent controlled exposures to 25°C and 5°C.
  • Propranolol was administered to block beta-adrenergic pathways involved in nonshivering thermogenesis.
  • Metabolic heat production (VO2) and shivering (EMG) were measured during rest and treadmill exercise.

Main Results:

  • Body core and mean skin temperatures were significantly lower in the 5°C environment compared to 25°C.
  • Thermoregulatory VO2 (TVO2) was significantly reduced when nonshivering thermogenesis was blocked by propranolol during both rest and exercise.
  • Shivering activity (EMG) was elevated in the cold, but not significantly different between drug and placebo conditions.

Conclusions:

  • Nonshivering thermogenesis plays a significant role in metabolic heat production during acute cold exposure in humans.
  • Pharmacological blockade with propranolol effectively attenuates nonshivering thermogenesis, reducing overall heat production.
  • These findings highlight the importance of nonshivering thermogenesis for maintaining thermal balance in cold environments.

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