Targeting of non-small cell lung cancer using HMFG1-99mTc monoclonal antibodies

Anti HMFG1 monoclonal antibodies labeled with 99mTc were used for the detection of non-small cell lung cancers and their metastases in 18 patients (12 squamous cell cancers, 2 large cell lung cancers, 1 adenocarcinoma and 3 undifferentiated non-small cell lung cancer). According to performed therapy all patients were divided into three groups: group 1 consisted of 13 patients who had not received chemotherapy or radiotherapy before immunoscintigraphy (IS), group 2 included 3 patients who had undergone IS during external beam radiotherapy, and group 3 (two patients) who had received both chemotherapy and radiotherapy before IS. After antibody administration planar scintigraphy of the head and neck, chest in anterior and posterior projection, anterior abdomen, pelvis, thighs and calves was obtained at 10 minutes, 5 hours and 24 hours. The scans were interpreted semi-quantitatively using T/NT ratio. In the first group IS was found true positive in 5/13 patients (38%), and T/NT ratio ranged from 1.3-1.5. In the second group all three patients were true positive and T/NT ratio ranged from 1.76 to 2.1. In the third group both patients were found false negative. Successful metastases detection was found in 4/13 patients (30%).