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[Atypical optic neuritis in systemic lupus erythematosus (SLE)]
A Eckstein1, I Kötter, H Wilhelm
1Augenklinik der Universität Tübingen.
Klinische Monatsblatter Fur Augenheilkunde
|November 1, 1995
Summary
This case study highlights autoimmune optic neuritis in an elderly woman with lupus. Prompt corticosteroid treatment led to significant vision recovery, emphasizing early intervention.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Autoimmune optic neuritis is a rare condition.
- Systemic lupus erythematosus (SLE) can affect the optic nerve.
Observation:
- A 67-year-old woman with a 30-year history of renal insufficiency presented with acute unilateral visual loss and pain.
- She exhibited a relative afferent pupillary defect and visual field defects, with optic discs initially normal but later showing blurred margins.
- Immunoserologic tests revealed elevated antinuclear antibody (ANA) and anti-double-stranded DNA (DS-DNA) antibody titers.
Findings:
- The patient was diagnosed with atopic optic neuritis secondary to SLE.
- Treatment with high-dose prednisolone resulted in significant visual acuity improvement and visual field normalization within 6 weeks.
Implications:
- Autoimmune optic neuritis, particularly in older patients with systemic disease (atopic optic neuritis), often responds well to corticosteroid therapy.
- Early diagnosis and treatment initiation are crucial for favorable visual outcomes.
- Immunopathologic findings are vital for diagnosing atopic optic neuritis and can inform management of the underlying autoimmune condition.