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C-cell distribution in ovine thyroid gland

H Okada1, Y Shigeta, Y Un-No

  • 1Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.

Anatomia, Histologia, Embryologia
|December 1, 1995
PubMed
Summary

Researchers studied sheep thyroid C-cells using digital imaging. C-cells concentrate centrally in thyroid lobes, showing a strong correlation between cell number and percentage, with no sex-based differences in 2-3-year-old sheep.

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Area of Science:

  • Veterinary Anatomy
  • Endocrinology
  • Histology

Background:

  • C-cells, also known as parafollicular cells, are crucial endocrine cells within the thyroid gland.
  • Their distribution and density can vary based on species, age, and physiological state.
  • Understanding C-cell distribution is important for interpreting thyroid function and potential pathologies.

Purpose of the Study:

  • To quantify the number and percentage of C-cells per unit area in the thyroid glands of 2-3-year-old sheep.
  • To determine the topographical distribution of C-cells within the thyroid lobes.
  • To investigate potential correlations between C-cell number and percentage, and differences between sexes.

Main Methods:

  • Immunoperoxidase staining technique was employed to identify C-cells.

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  • Digital-image analysis was utilized for quantitative assessment.
  • Thyroid glands from 2-3-year-old sheep were examined.

    • Main Results:

    • C-cells were found throughout the thyroid lobes, excluding the isthmus and poles.
    • A higher concentration of C-cells was observed in the deep central regions, with density decreasing towards the periphery.
    • A high correlation was found between the number and percentage of C-cells per unit area.
    • No significant differences in C-cell distribution were noted between male and female sheep.

    Conclusions:

    • Sheep thyroid C-cells exhibit a distinct central-to-peripheral gradient within the lobes.
    • The number and percentage of C-cells are highly correlated, suggesting a consistent cellular density.
    • Age and sex do not appear to significantly influence C-cell distribution in young adult sheep.