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Adaptation of the temporomandibular joint to altered mandibular function
D L Johnson1, J W Brand, S K Young
1College of Dentistry, University of Oklahoma, Oklahoma City, USA.
The International Journal of Prosthodontics
|September 1, 1995
Summary
This pilot study investigated rat responses to induced mandibular retrusion, finding reduced activity and food intake. Histology showed minimal inflammation, primarily a monocytic infiltrate at 4 days.
Area of Science:
- Comparative physiology
- Dental biomechanics
- Animal models in research
Background:
- Mandibular retrusion can affect physiological functions.
- Understanding the biological response to dental interventions is crucial.
- Pilot studies are essential for evaluating novel approaches.
Purpose of the Study:
- To assess the physiological and histological effects of induced mandibular retrusion in Sprague Dawley rats.
- To evaluate the impact of lingually overcontoured crowns on rat behavior and nutrition.
- To determine the inflammatory response following induced autoretrusion.
Main Methods:
- Inducing 3.5 mm of mandibular autoretrusion using lingually overcontoured maxillary incisor crowns in Sprague Dawley rats.
- Monitoring animal activity levels and nutritional intake.
- Conducting histological evaluations of dental tissues at 2, 4, 7, and 59 days post-intervention.
Main Results:
- Significant suppression of general activity was observed.
- A notable reduction in nutritional intake was recorded.
- Histological analysis revealed a transient monocytic infiltrate, predominantly at the 4-day mark, with minimal other inflammatory responses.
Conclusions:
- Induced mandibular retrusion in rats leads to behavioral and nutritional deficits.
- The observed monocytic infiltrate suggests a localized, short-term inflammatory response.
- Further research is warranted to explore long-term effects and potential clinical implications.