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Updated: Aug 13, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Basal cell carcinoma. Identification and treatment of the high-risk patient
1Department of Dermatology, Mayo Clinic Jacksonville, FL 32224, USA.
Background:
Some cutaneous basal cell carcinomas have a significant potential to recur, disfigure, and metastasize.
Objectives And Methods:
The identification and selection of treatment of these high risk carcinomas is based on a review of studies of recurrence, giant size, metastasis, and mortality.
Results:
Basal cell carcinomas with any of the following: long duration, location in the mid face or ear, larger than 2 cm, with aggressive histologic subtype, previous treatment, neglected, or a history of radiation exposure, should be considered "high risk."
Conclusion:
For basal cell carcinomas with this high risk profile, complete excision by margin control or total destruction should be considered.

