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Calcifying basal cell carcinomas

J S Walsh1, C Perniciaro, H W Randle

  • 1Department of Dermatology, Mayo Clinic Jacksonville, Florida 32224, USA.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|February 6, 1999
PubMed
Summary
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Dystrophic calcification is more common in basal cell carcinomas (21%) than squamous cell carcinomas (3%). This finding may indicate a marker for follicular differentiation in skin cancers.

Area of Science:

  • Dermatopathology
  • Oncology
  • Biochemistry

Background:

  • Dystrophic calcification involves calcium deposition in injured tissues.
  • Little is understood about dystrophic calcification in malignant skin tumors.

Purpose of the Study:

  • To determine the frequency and pattern of dystrophic calcification in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs).

Main Methods:

  • Reviewed 200 consecutive cases of BCC and SCC for dystrophic calcification.
  • Noted histologic subtype, calcification location, and tumor site.

Main Results:

  • Dystrophic calcification was found in 41% of BCCs versus 6% of SCCs.
  • Calcifying BCCs were associated with more aggressive histologic subtypes and trunk location.

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Conclusions:

  • Skin calcium binding protein may explain the calcification frequency difference between BCCs and SCCs.
  • Calcification in keratin-filled cysts suggests a potential marker for follicular differentiation in skin tumors.