Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Deleterious background selection with recombination

R R Hudson1, N L Kaplan

  • 1Department of Ecology and Evolutionary Biology, University of California, Irvine 92717, USA. rhudson@uci.edu

Genetics
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants.

American journal of human genetics·2005
Same author

Type I error and the power of the s-test: old lessons from a new, analytically justified statistical test for phylogenies.

Systematic biology·2002
Same author

Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs.

Theoretical population biology·2002
Same author

Analysis of single nucleotide polymorphisms in candidate genes using the pedigree disequilibrium test.

Genetic epidemiology·2002
Same author

Two-locus sampling distributions and their application.

Genetics·2002
Same author

Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels.

American journal of human genetics·2001
Same journal

Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.

Genetics·2026
Same journal

Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

Genetics·2026
Same journal

Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

Genetics·2026
Same journal

Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

Genetics·2026
Same journal

Identification of two Cryptococcus neoformans heme transporters involved in Fhb1-mediated nitrosative stress protection in a fission yeast model.

Genetics·2026
Same journal

Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics.

Genetics·2026
See all related articles

Researchers developed a model for nucleotide diversity considering harmful mutations and recombination. While it explains variation near centromeres in Drosophila melanogaster, it requires adjusted parameters to match low variation levels at chromosome tips.

Area of Science:

  • Population Genetics
  • Molecular Evolution
  • Genomics

Background:

  • Understanding genetic variation is crucial for evolutionary studies.
  • Deleterious mutations and recombination significantly impact patterns of genetic diversity.
  • The third chromosome of Drosophila melanogaster serves as a model system for studying genome-wide variation.

Purpose of the Study:

  • To derive an analytic expression for expected nucleotide diversity at neutral loci.
  • To model genetic variation across the Drosophila melanogaster third chromosome.
  • To test the consistency of the background selection model with observed variation patterns.

Main Methods:

  • Developed an analytic expression incorporating deleterious mutation and recombination.
  • Applied the model to predict nucleotide diversity across the entire third chromosome.

Related Experiment Videos

  • Compared model predictions with empirical data on genetic variation in Drosophila melanogaster.

    • Main Results:

    • The model accurately predicts low nucleotide diversity near centromeres.
    • Observed low variation at chromosome tips is not fully explained by current parameter estimates.
    • Adjusting selection coefficients for deleterious mutations reconciles tip variation with background selection.

    Conclusions:

    • The background selection model provides a framework for understanding nucleotide diversity.
    • Deleterious mutation rates and selection coefficients are critical parameters influencing variation patterns.
    • Further refinement of these parameters is needed to fully explain Drosophila melanogaster chromosome tip variation.