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Budding yeast morphogenesis: signalling, cytoskeleton and cell cycle

S J Kron1, N A Gow

  • 1Whitehead Institute for Biomedical Research, Cambridge, USA. kron@wi.mit.edu

Current Opinion in Cell Biology
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

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Nutritional signals guide Saccharomyces cerevisiae cell development, influencing shape and gene expression. This yeast cell-type transition relies on regulating basic functions like cytoskeletal organization and cell cycle progression.

Area of Science:

  • Mycology
  • Cell Biology
  • Biochemistry

Background:

  • Saccharomyces cerevisiae exhibits diverse cell types with distinct morphologies, gene expression profiles, and growth patterns.
  • Signal transduction pathways are crucial for mediating cell type transitions in response to environmental cues.
  • Nutritional signals trigger significant cellular changes, including transitions from yeast-form to invasive growth or cell cycle arrest.

Purpose of the Study:

  • To elucidate the mechanisms by which nutritional signals regulate cell type transitions in Saccharomyces cerevisiae.
  • To investigate the role of signal transduction in mediating developmental changes in yeast.
  • To understand how differential regulation of vegetative functions contributes to cell type specificity.

Main Methods:

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  • Observational studies on Saccharomyces cerevisiae under varying nutritional conditions.
  • Analysis of gene expression patterns associated with different cell types and growth modes.
  • Investigation of signal transduction pathway activation during cell type transitions.
  • Examination of cytoskeletal organization and cell cycle progression during development.

    • Main Results:

    • Nutritional signals induce distinct developmental pathways, leading to either invasive filamentous growth or arrest for stationary phase, conjugation, or meiosis.
    • Cell type transitions are mediated by specific signal transduction pathways.
    • Differential regulation of fundamental cellular processes, such as cytoskeletal organization and cell cycle progression, is critical for development.
    • Expression of cell-type-specific gene products works in concert with regulation of vegetative functions.

    Conclusions:

    • Cell type diversification in Saccharomyces cerevisiae is a complex process regulated by external nutritional cues via signal transduction.
    • Developmental plasticity in yeast depends on the coordinated regulation of both specialized gene products and core vegetative functions.
    • Understanding these regulatory mechanisms provides insight into fungal development and cellular differentiation.