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Specificity and effector-target interaction

M Takasugi

    National Cancer Institute Monograph
    |December 1, 1978
    PubMed

    When effector cells were tested on a number of target cells, the most obvious effect observed was a nonselective cytotoxicity that is now known as natural cell-mediated cytotoxicity. The apparent nonselectivity was a result of specific cytotoxic activity against many different antigens on target cells. This specificity was demonstrated in the cross-competition assay in which target cells sharing common antigens selectively inhibited natural cytotoxicity.

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