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Asthma treatment in schoolchildren: lung function in different therapeutic groups
Acta Paediatrica (Oslo, Norway : 1992)
|February 1, 1996
Summary
Children with asthma on maintenance therapy, including cromones or budesonide, maintained lung function above 90% of predicted values. Clinical selection for asthma treatment groups was adequate, with cromones suitable for many children.
Area of Science:
- Pediatric Pulmonology
- Asthma Management
- Clinical Pharmacology
Background:
- Asthma management in children requires effective treatment strategies.
- International consensus statements guide asthma therapy selection.
- Assessing lung function is crucial for monitoring asthma control.
Purpose of the Study:
- To evaluate lung function in school-aged children with asthma based on their maintenance therapy.
- To determine the adequacy of clinical selection for different asthma treatment groups.
- To assess the suitability of cromones for managing childhood asthma.
Main Methods:
- Dynamic spirometry and peak expiratory flow measurements were performed on 297 children with asthma.
- Children were categorized into three treatment groups: no maintenance drugs, cromones (cromoglycate or nedocromil), or budesonide.
- Lung function parameters including PEF, FVC, FEV1, FEV%, and MMEF were compared against reference values.
Main Results:
- Mean lung function values (PEF, FVC, FEV1, FEV%) were consistently above 90% of predicted values across all treatment groups.
- The mean FEV1/FVC ratio exceeded 85%, and mean MMEF exceeded 75% of reference values.
- Minor differences in lung function were observed between therapeutic groups, indicating adequate clinical selection.
Conclusions:
- Clinical selection of asthma treatment in children based on established guidelines is effective.
- Children treated with cromones or budesonide demonstrated good lung function.
- Cromones are a viable maintenance therapy option for a significant proportion of children with asthma.