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Wine and headache

R Jarisch1, F Wantke

  • 1Dermatologic and Pediatric Allergy Clinic, Vienna, Austria.

International Archives of Allergy and Immunology
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Histamine intolerance, caused by low diamine oxidase activity, can trigger headaches from wine and certain foods. A histamine-free diet and avoiding alcohol are key treatments for this condition.

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Area of Science:

  • Gastroenterology
  • Neurology
  • Biochemistry

Background:

  • Histamine intolerance is a condition characterized by impaired histamine degradation due to reduced diamine oxidase (DAO) activity.
  • DAO, crucial for metabolizing histamine, is found in the jejunal mucosa and is inhibited by alcohol and certain drugs.
  • Reduced DAO activity leads to histamine accumulation, potentially causing headaches, particularly from histamine-rich foods like wine.

Purpose of the Study:

  • To investigate the role of histamine and diamine oxidase in wine-induced headaches in patients with histamine intolerance.
  • To explore the efficacy of a histamine-free diet and supportive treatments for managing histamine intolerance and associated headaches.

Main Methods:

  • Assessed diamine oxidase (DAO) activity levels in patients with histamine intolerance and compared them to healthy controls.

Related Experiment Videos

  • Experimental models were used to induce headaches via histamine infusion and red wine provocation.
  • Evaluated the impact of a histamine-free diet, antihistamines, and vitamin B6 supplementation on patient symptoms and DAO activity.

    • Main Results:

    • Patients with histamine intolerance exhibited significantly lower DAO activity (0.03 nKat/l) compared to healthy individuals (0.07 nKat/l).
    • Histamine infusion and red wine successfully induced headaches in experimental models, suggesting a causal link.
    • A histamine-free diet, combined with vitamin B6, showed clinical improvement in patients, confirming the diagnosis through in vitro tests.

    Conclusions:

    • Histamine intolerance, stemming from reduced DAO activity, is a significant cause of chronic headaches triggered by wine and food.
    • A histamine-free diet is the primary treatment, alongside avoiding DAO-inhibiting substances like alcohol and certain medications.
    • Vitamin B6 (pyridoxal phosphate) supplementation may support DAO function and improve outcomes for histamine-intolerant individuals.