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Updated: Sep 7, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 26, 2016
[Molecular analysis of the heterogeneity of hereditary monosymptomatic sensorineural hearing loss]
P Fiegert1, A Lamprecht-Dinnesen, S Preisler-Adams
1Poliklinik für Phoniatrie und Pädaudiologie, Westfälische Wilhelms-Universität Münster.
Background:
Genetic characterization of hereditary hearing impairment has progressed considerably with the mapping of nine chromosomal loci for monosymptomatic autosomal-inherited hearing loss over the last three years.
Methods:
Following thorough clinical evaluation, linkage analysis using microsatellite markers was performed in two large families from Westphalia/West Germany.
Results:
For all the dominant (DFNA1--4) and three autosomal-recessive loci (DFNB1--3) described to date, linkage was finally excluded.
Conclusions:
A high degree of genetic heterogeneity must be assumed. Identification of individual genes for monosymptomatic sensorineural hearing loss by linkage analysis in large pedigrees may help in molecular differentiation of hearing.

