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Chrysiasis after low-dose gold and UV light exposure
C J Fleming1, E L Salisbury, P Kirwan
1Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Journal of the American Academy of Dermatology
|February 1, 1996
Summary
A rare skin condition called chrysiasis developed in a woman after low-dose gold therapy. Intense UV light exposure in Australia may have contributed to its development.
Area of Science:
- Dermatology
- Toxicology
- Medical Imaging
Background:
- Chrysiasis is a rare, permanent skin discoloration caused by gold deposition.
- Gold therapy has been used historically for conditions like rheumatoid arthritis.
Observation:
- A 54-year-old woman developed chrysiasis.
- The condition appeared after relatively low-dose gold administration.
- The patient had significant exposure to intense ultraviolet (UV) light in Australia.
Findings:
- Diagnosis was confirmed using light microscopy, transmission electron microscopy, and radiographic microanalysis.
- Gold deposition in the skin was identified as the cause.
- A potential link between gold deposition and UV light exposure is suggested.
Implications:
- This case highlights chrysiasis as a potential side effect of gold therapy, even at low doses.
- Intense UV light exposure may be a contributing factor in the development of chrysiasis.
- Further research is needed to understand the interaction between gold deposition and UV radiation in skin.