Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in renal function in primary hypothyroidism

J Montenegro1, O González, R Saracho

  • 1Service of Nephrology, Hospital de Galdakao, Galdácano, Vizcaya, Spain.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visual evoked potentials and development on children with congenital cataract with surgery after 4 months of age.

Archivos de la Sociedad Espanola de Oftalmologia·2025
Same author

Inhibition of calreticulin by protein nanoparticles carrying antisense oligonucleotides reduce gene expression and infection of <i>Trypanosoma cruzi</i> trypomastigotes on mammalian cells.

Nanomedicine (London, England)·2025
Same author

Production of poly-3-hydroxybutyrate (PHB) nanoparticles using grape residues as the sole carbon source.

International journal of biological macromolecules·2024
Same author

Clinical findings, surgical treatment and outcome in dogs with parotid duct ectasia: 14 cases (2010-2023).

The Journal of small animal practice·2023
Same author

[Translated article] Tumor ablation and vertebral augmentation in the treatment of vertebral metastases: A multicenter study.

Revista espanola de cirugia ortopedica y traumatologia·2023
Same author

Major Fusarium species and mycotoxins associated with freshly harvested maize grain in Uruguay.

Mycotoxin research·2023
Same journal

Palliative Dialysis: Putting the Person First in Dialysis Care.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Associations of Pre-Pandemic CKD With Acute and Post-Acute COVID-19: The C4R Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Metabolic Acidosis and Progression of CKD: Current Guidelines and Considerations.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Pathophysiology of Ketoacidosis: Core Curriculum 2026.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Mitochondrial Alterations and CKD.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Kidney Transplant Access for Persons Who Are Incarcerated: A Call for Action.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
See all related articles

Hypothyroidism can subtly impair kidney function and cause electrolyte imbalances like hyponatremia. Thyroid hormone replacement therapy effectively corrected these renal defects in patients with primary hypothyroidism.

Area of Science:

  • Nephrology
  • Endocrinology
  • Internal Medicine

Background:

  • Renal function impairment and electrolyte disorders in hypothyroidism are often subtle.
  • These subclinical defects can be overlooked in routine clinical practice.

Purpose of the Study:

  • To assess the extent of renal function impairment and electrolyte disorders in primary hypothyroidism.
  • To evaluate the effects of thyroid hormone replacement therapy on these defects.

Main Methods:

  • Studied 41 patients with primary hypothyroidism.
  • Measured serum electrolytes and glomerular filtration rate (GFR) before and after treatment.
  • Assessed serum creatinine and correlated findings with age and thyrotropin-stimulating hormone (TSH).

Related Experiment Videos

Main Results:

  • All patients exhibited decreased GFR; 22 had elevated serum creatinine.
  • Hyponatremia was more prevalent in patients with higher serum creatinine.
  • No significant correlation was found between creatinine clearance and TSH levels.
  • A weak correlation between age and serum creatinine was observed.

Conclusions:

  • Primary hypothyroidism is associated with mild creatinine clearance reduction, more pronounced in elderly patients.
  • Impaired renal function in hypothyroidism correlates with a higher incidence of hyponatremia.
  • Thyroid hormone replacement therapy successfully reversed renal function and electrolyte abnormalities.