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Updated: Aug 10, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
Published on: July 30, 2014
HIV-1 Gag protein associates with F-actin present in microfilaments
1Department of Pediatrics, School of Medicine, University of California at Los Angeles 90095, USA. <orey@pediatrics.medsch.ucla.edu>
Abstract:
Several studies have provided evidence that the cellular cytoskeleton may be involved in the assembly and budding of retroviruses. In fractionation studies of HIV-1-infected CEM cells, the majority of the unprocessed Gag polyprotein cofractionated with the cellular cytoskeleton. In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1.
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