[Mechanisms of neuroplasticity]

Primary organization of the neuronal circuits is based on the genetic program. In addition, individual elements of these circuits are able to adjust their function and structure to the changes in external and internal conditions. In a given moment, formation and rearrangement of the neuronal circuits are based on the mutual cooperation between mechanisms assuring plasticity and rigidity. Plasticity is related not only to the development of the organism or to changes in the internal or external conditions, it may also reflect the progress of some pathological states or the recovery of an injured nervous structure. Intensification of the natural neuroplastic mechanisms or the introduction of an active (or activated) neuronal tissue into the impaired circuits might improve the process of recovery in the central nervous system.