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Influence of sufentanil on propofol anesthesia using a target controlled infusion system
G J Los1, M H Lauwers, C Van Lersberghe
1Department of Anesthesiology, Flemish Free University of Brussels Medical Center, Brussels, Belgium.
Acta Anaesthesiologica Belgica
|January 1, 1995
Summary
Increasing sufentanil dosage did not significantly alter anesthesia induction or recovery times in patients receiving propofol target-controlled infusion. Recovery was primarily dependent on the total propofol dose administered during the procedure.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Propofol target-controlled infusion (TCI) is widely used for general anesthesia.
- Sufentanil is an opioid commonly used as an adjunct to anesthesia.
Purpose of the Study:
- To evaluate the impact of varying sufentanil dosages on propofol TCI anesthesia characteristics.
- To determine if increased sufentanil affects induction, maintenance, and recovery phases.
Main Methods:
- Twenty-four patients undergoing laparoscopic cholecystectomy were randomly assigned to three sufentanil dosing groups (bolus and infusion).
- Propofol anesthesia was maintained using TCI, titrated to hemodynamic stability.
- Induction, maintenance, and recovery parameters, including propofol blood concentrations, were recorded.
Main Results:
- A threefold increase in sufentanil dosing did not significantly alter induction or recovery times.
- Recovery times were predominantly influenced by the total amount of propofol administered.
- Predicted propofol blood concentrations at induction, maintenance, and recovery were not significantly affected by sufentanil dosage.
Conclusions:
- Sufentanil dosage does not significantly impact the timing of induction or recovery during propofol TCI anesthesia.
- The total propofol dose is the primary determinant of recovery characteristics.
- Anesthesiologists can maintain hemodynamic stability with varying sufentanil doses without compromising recovery timing.