Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acetaminophen/aspirin mixtures: experimental data

G A Porter1

  • 1Department of Medicine, University of Oregon Health Science Center, Portland, OR 97201, USA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, London, Ont., Sept. 19 to 22, 2002.

Canadian journal of surgery. Journal canadien de chirurgie·2023
Same author

Cross-Canada differences in early-stage breast cancer treatment and acute-care use.

Current oncology (Toronto, Ont.)·2019
Same author

ORE identifies extreme expression effects enriched for rare variants.

Bioinformatics (Oxford, England)·2019
Same author

First Report of White Mold (Sclerotinia sclerotiorum) on Soybean in Maine.

Plant disease·2019
Same author

The role of scientific evidence in decisions to adopt complex innovations in cancer care settings: a multiple case study in Nova Scotia, Canada.

Implementation science : IS·2019
Same author

Patterns of cancer centre follow-up care for survivors of breast, colorectal, gynecologic, and prostate cancer.

Current oncology (Toronto, Ont.)·2017
Same journal

Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)-Induced Hypophosphatemia.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Kidney Transplantation Post-Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Multiple Myeloma.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Palliative Dialysis: Putting the Person First in Dialysis Care.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Associations of Pre-Pandemic CKD With Acute and Post-Acute COVID-19: The C4R Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Metabolic Acidosis and Progression of CKD: Current Guidelines and Considerations.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Pathophysiology of Ketoacidosis: Core Curriculum 2026.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
See all related articles

Aspirin appears to be the most nephrotoxic common analgesic in animal studies. Combining aspirin with other analgesics may increase kidney damage, warranting further investigation into combination products.

Area of Science:

  • Nephrology
  • Toxicology
  • Pharmacology

Background:

  • Analgesic nephropathy is a significant clinical concern.
  • Experimental models are crucial for understanding drug-induced kidney damage.
  • The nephrotoxicity of commonly available analgesics requires thorough evaluation.

Purpose of the Study:

  • To review the literature on experimentally induced analgesic nephropathy.
  • To identify the most nephrotoxic analgesics based on animal studies.
  • To assess the risks associated with combined analgesic use.

Main Methods:

  • Literature review of experimental studies on analgesic nephropathy.
  • Analysis of animal models exhibiting chronic analgesic nephropathy.
  • Histopathologic examination of kidney tissues from intoxicated animals.

Related Experiment Videos

Main Results:

  • Aspirin demonstrated the highest nephrotoxicity among tested analgesics in animal models.
  • Combination analgesics, particularly with aspirin, suggest additive or synergistic nephrotoxic effects.
  • Histological differences observed between acute and chronic analgesic intoxication.

Conclusions:

  • Aspirin is a primary concern for analgesic nephrotoxicity in experimental settings.
  • Combination analgesic products may pose a heightened risk of kidney damage.
  • Further research is needed to clarify the role of combination analgesics in experimental nephrotoxicity.