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[Hemorrhagic shock and fulminant hepatic failure associated with valproate]
F J Fernandez-Fernandez1, J Garcia-Rego, A Garcia-Jimenez
1Servicio de Medicina Interna, Universidad de Santiago de Compostela, La Coruña.
Anales De Medicina Interna (Madrid, Spain : 1984)
|December 1, 1995
Abstract:
Fulminant hepatic failure is an uncommon adverse effect of valproate treatment. Despite an increased use of valproate, since the drug was introduced in 1978, a decline in the number of reported cases has been observed. Here a case of hemorrhagic shock and fulminant hepatic failure in a patient treated with valproate is presented. We emphasize the diagnostic difficulties from the point of view of recognition of the clinical manifestations as well as the biochemical monitoring.