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ARF-regulated phospholipase D: a potential role in membrane traffic
1Department of Physiology, University College London, UK. ucgbsxc@ucl.ac.uk
Chemistry and Physics of Lipids
|May 24, 1996
Summary
ADP ribosylation factor (ARF), a GTP-binding protein, regulates phospholipase D activity. This review connects ARF
Area of Science:
- Cell biology
- Molecular biology
- Biochemistry
Background:
- Phospholipase D (PLD) activity is rapidly activated by cell-surface receptor signaling.
- ADP ribosylation factor (ARF) is an identified intracellular regulator of PLD.
- ARF is a small GTP-binding protein known for its role in vesicular transport.
Purpose of the Study:
- To review the connection between signal transduction and vesicular transport.
- To elucidate the role of ARF in regulating Phospholipase D activity.
Main Methods:
- Literature review of studies on ARF, PLD, signal transduction, and vesicular transport.
Main Results:
- ARF acts as a key regulator linking cell surface receptor signals to downstream events.
- The function of ARF in vesicular transport is intertwined with its role in signal transduction pathways.
Conclusions:
- Understanding the dual role of ARF in signal transduction and vesicular transport provides a unified view of cellular regulation.
- This review highlights the convergence of two major fields in cell biology through the study of ARF.