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Updated: Aug 30, 2026

In vitro Functional Characterization of Mouse Colorectal Afferent Endings
Published on: January 21, 2015
Gastrointestinal sensation. Mechanisms and relation to functional gastrointestinal disorders
M Camilleri1, S B Saslow, A E Bharucha
1Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA.
Abstract:
This article reviews the basic anatomy and physiology of visceral afferent function and its application to a clearer understanding of visceral pain and symptoms in patients with functional gastrointestinal disorders. Recent investigations have focused on the potential role of visceral tone, different afferent (A delta and C) fibers, dorsal column neurons, and supraspinal modulation in the elicitation of visceral perception of noxious and nonnoxious stimuli arising in the gut. Greater understanding of these pathomechansims and their pharmacologic manipulation offers an opportunity for future therapeutic strategies for these disorders.
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