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[Pancreas transplantation--indication, technique and results]
M Schilling1, H P Marti, H Friess
1Klinik für Viszerale- und Transplantationschirurgie, Universität Bern, Inselspital.
Therapeutische Umschau. Revue Therapeutique
|May 1, 1996
Summary
Pancreas transplantation offers diabetic patients long-term normal blood sugar and HbA1c levels. However, it requires lifelong immunosuppression, leading to combined kidney-pancreas transplants for those with diabetic nephropathy.
Area of Science:
- Nephrology
- Endocrinology
- Transplantation immunology
Context:
- Pancreas transplantation is the sole treatment for achieving long-term normoglycemia and normal HbA1c in diabetic patients.
- Lifelong immunosuppression is necessary, carrying significant side effects.
- Combined kidney-pancreas transplantation is often preferred for patients with diabetic nephropathy.
Purpose:
- To review the indications, techniques, results, and complications of simultaneous kidney-pancreas transplantation (SKPT) and pancreas after kidney transplantation (PAK).
Summary:
- This review covers SKPT and PAK, focusing on their role in managing diabetes and kidney disease.
- It details the surgical procedures, outcomes, and potential adverse events associated with these combined transplant strategies.
- The article highlights the benefits of pancreas transplantation in achieving glycemic control while acknowledging the associated risks of immunosuppression.
Impact:
- Provides a comprehensive overview for clinicians considering pancreas transplantation in diabetic patients with renal complications.
- Aids in understanding the risks and benefits of combined versus sequential kidney and pancreas transplantation.
- Contributes to the decision-making process for managing end-stage renal disease in diabetic populations.