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Acetogenins from Annonaceae, inhibitors of mitochondrial complex I
M C Zafra-Polo1, M C González, E Estornell
1Departamento de Farmacología (Farmacognosia y Farmacodinamia), Facultad de Farmacia, Universidad de Valencia, Spain.
Phytochemistry
|May 1, 1996
Abstract:
One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).