[Cutaneous symptoms after continuous subcutaneous injection of morphine]

We present two cases of patients who developed local swelling and induration after continuous subcutaneous infusion of morphine. Cutaneous complications of repeated subcutaneous injections of pentazocine, meperidine, ketobemidone and methadone are well described. There are few reports of similar reactions after subcutaneous administration of morphine. Both patients were later treated with sufentanil using the subcutaneous route without any reaction. Sufentanil might be an alternative to patients who cannot tolerate morphine.