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CD28/B7 system of T cell costimulation

D J Lenschow¹, T L Walunas, J A Bluestone

¹Committee on Immunology, Ben May Institute, Chicago, Illinois 60637, USA.

Annual Review of Immunology

|January 1, 1996

Summary

The CD28/B7 pathway is crucial for T cell activation and immune regulation. Understanding its complex interactions is key to developing new therapies for immune suppression and tolerance.

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Area of Science:

Immunology
Molecular Biology
Cell Signaling

Background:

T cells are central to immune responses, requiring TCR engagement and co-stimulatory signals for activation.
The CD28/B7 receptor/ligand system is a dominant co-stimulatory pathway influencing T cell responses.
Interruption of CD28/B7 signaling can suppress immune responses or induce antigen-specific tolerance.

Purpose of the Study:

To review the current understanding of CD28/B7 immunobiology.
To summarize experimental findings on CD28/B7 pathway participants.
To illustrate models of CD28/B7-mediated T and B cell regulation.

Main Methods:

Literature review of in vitro and in vivo studies.
Analysis of experimental data on CD28/B7 interactions.
Synthesis of current models of immune cell regulation.

Main Results:

The CD28/B7 system involves multiple receptors and ligands with diverse signaling roles.
CD28/B7 interactions are critical for both T cell activation and regulation.
Complexities in the CD28/B7 system necessitate further research.

Conclusions:

The CD28/B7 pathway's complexity impacts immune responses and therapeutic strategies.
Further research is needed to fully elucidate the CD28/B7 signaling pathway.
Understanding this pathway can lead to novel approaches for immune modulation.

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