[Kinetics of nerve ending ion currents with nonhomogeneous distribution of ion channel density]

The Hodgkin-Huxley's equations of unmyelinated nerve fiber's electric behaviour has been used to create model of nerve endings electrogenesis. The Eler's integration method has been applied to solve the partial differential equation system which describes the spread of excitation in nerve ending. The effect of nonhomogeneous distribution densities of ionic channels along nerve ending on the ionic currents were simulated. The comparison of computed curves with nerve ending responses recorded by extracellular electrodes was performed. It was shown that the better match between simulated and recorded responses observes during densities' decrease potential-dependent sodium, potassium and calcium-activated potassium channels according to exponent along the nerve ending without changes of calcium channels density. As the result the amplitude and time-course of spread action potential, calcium current and transmitter release along the nerve ending appear to be changed.