Hemodynamic changes as triggers of cardiovascular events

Although a large number of clinical studies during the past decade have documented that myocardial ischemia, acute myocardial infarction, and sudden cardiac death have definite circadian patterns, recently published work suggests that it is not necessarily a specific time of the day but the sleep/wake cycle and postural changes as well as the balance between triggers and protective factors that determine the onset of cardiovascular events. A clear understanding of the pathophysiologic processes responsible for ischemic events and the specific roles played by various triggers would be helpful in better defining the therapeutic strategies designed for the prevention and treatment of acute cardiac events. Because changes in hemodynamic parameters are of paramount importance in initiating an ischemic event, it is critical to review their role and relationship in the pathogenesis of acute coronary events.