Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Potential energy functions for threading

D T Jones1, J M Thornton

  • 1Department of Biological Sciences, University of Warwick, Coventry, UK. jones@globin.warwick.ac.uk

Current Opinion in Structural Biology
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Large-scale annotation of biochemically relevant pockets and tunnels in cognate enzyme-ligand complexes.

Journal of cheminformatics·2024
Same author

Brain charts for the human lifespan.

Nature·2022
Same author

Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection.

Prostaglandins & other lipid mediators·2022
Same author

Changes in Ventricular and Cortical Volumes following Shunt Placement in Patients with Idiopathic Normal Pressure Hydrocephalus.

AJNR. American journal of neuroradiology·2021
Same author

Lipoxin A4 promotes reduction and antibiotic efficacy against Pseudomonas aeruginosa biofilm.

Prostaglandins & other lipid mediators·2020
Same author

Studies on Clostridium acetobutylicum ginA promoters and antisense RNA.

Molecular microbiology·2017
Same journal

Metabolic disruptions through a three-dimensional genomic lens.

Current opinion in structural biology·2026
Same journal

Collective variable design for biomolecular conformational dynamics.

Current opinion in structural biology·2026
Same journal

Polymer scaling in protein crowding: From dilute coils to semidilute meshes.

Current opinion in structural biology·2026
Same journal

Tuning the physicochemical properties of rationally designed protein-based biomolecular condensates.

Current opinion in structural biology·2026
Same journal

Macromolecular crowding reshapes the conformational landscapes of intrinsically disordered proteins: mechanisms, cellular contexts, and functional consequences.

Current opinion in structural biology·2026
Same journal

Beyond structure: spectroscopic imaging in cryogenic electron microscopy.

Current opinion in structural biology·2026
See all related articles

Protein structure prediction remains challenging, but fold-recognition methods offer promise. Ongoing research aims to improve the accuracy and sensitivity of these computational tools for tertiary structure determination.

Area of Science:

  • Computational Biology
  • Structural Biology
  • Bioinformatics

Background:

  • Predicting a protein's tertiary structure from its amino acid sequence (ab initio prediction) has seen limited progress.
  • Fold-recognition methods have emerged as a more encouraging approach in protein structure prediction over the last four years.

Purpose of the Study:

  • To highlight the progress and current limitations of fold-recognition methods in tertiary structure prediction.
  • To underscore the ongoing efforts to enhance the reliability and sensitivity of these computational tools.

Main Methods:

  • The study focuses on the development and application of fold-recognition techniques.
  • It reviews advancements in computational approaches for predicting protein three-dimensional structures.

Related Experiment Videos

Main Results:

  • Fold-recognition methods have shown promising initial results in tertiary structure prediction.
  • Despite progress, these methods are not yet fully mature or universally reliable.

Conclusions:

  • Fold-recognition represents a significant, albeit developing, area of advancement in protein structure prediction.
  • Continued research is essential to refine these methods for increased accuracy and broader applicability in structural biology.