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Updated: Jul 17, 2026
09:44
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
Database for sensorineural hearing loss
1Department of Otolaryngology, New York University School of Medicine, N.Y. 10016, USA.
International Journal of Pediatric Otorhinolaryngology
|April 1, 1996
Summary
Researchers are building a cell and DNA bank from deaf children and families to study hereditary deafness. A detailed database tracks clinical data to understand the causes and features of hearing loss.
Area of Science:
- Genetics
- Otolaryngology
- Bioinformatics
Background:
- Hereditary deafness is a significant cause of hearing loss.
- Understanding the molecular basis requires comprehensive genetic and clinical data.
- Existing data collection methods may lack standardization for familial studies.
Purpose of the Study:
- To present the design and content of a relational database for hereditary deafness.
- To facilitate the study of the molecular basis of sensorineural hearing loss.
- To provide a model for clinical data collection in deafness research.
Main Methods:
- Creation of a biobank with EBV immortalized lymphoblast cell lines and DNA from deaf individuals and relatives.
- Development of a computerized relational database to record detailed clinical data.
- Database organized into sections covering demographics, medical history, audiology, and genetic information.
Main Results:
- Established a comprehensive database correlating clinical features with genetic material.
- The data model identifies known etiologies and characterizes clinical phenotypes.
- The database includes extensive information from patient history, examinations, and diagnostic tests.
Conclusions:
- The developed database serves as a valuable resource for studying hereditary deafness.
- This model can be adopted by other researchers and clinicians for standardized data collection.
- Facilitates genetic research into the molecular underpinnings of hearing loss.
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