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Updated: Jul 25, 2026
A Method of Nodose Ganglia Injection in Sprague-Dawley Rat
Published on: November 25, 2014
Intravenous NPY (27-36)-D decreases cardiac output in conscious Sprague-Dawley rats
A K Roscoe1, J Nyce, W R Wooles
1Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Abstract:
Intravenous (IV) administration of NPY (27-36)-D, a substituted carboxyterminal fragment of neuropeptide Y (NPY), decreases mean arterial pressure (MAP) in normo-and hypertensive rats by a mechanism partially involving histamine receptors. The purpose of this study is to further characterize the cardiovascular effects of NPY (27-36)-D. NPY (27-36)-D dose-dependently decreased MAP, cardiac output, and stroke volume without significantly altering peripheral resistance. Myocardial contractility diminished by 151.2 +/- 31.8, 529.6 +/- 182.5, and 495.4 +/- 66.7 mmHg/s2 in rats treated with 300, 500, and 750 nmol/kg NPY (27-36)-D, respectively. Therefore, NPY (27-36)-D modifies MAP, in part, by a reversible negative inotropic effect on the heart.
