Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human mannan binding protein in pre-eclampsia

D C Kilpatrick1

  • 1Department of Transfusion Medicine, Edinburgh, Scotland, UK.

Immunology Letters
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can ficolin-2 (L-ficolin) insufficiency be established by a single serum protein measurement?

International journal of immunogenetics·2015
Same author

Drug modification of LPS-stimulated human monocyte-derived dendritic cells.

British journal of biomedical science·2012
Same author

Use of lectins as mitogens for lymphocytes.

Methods in molecular medicine·2011
Same author

Mechanisms and assessment of mitogenesis : an overview.

Methods in molecular medicine·2011
Same author

Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene.

Clinical and experimental immunology·2007
Same author

Association between mannan-binding lectin and impaired lung function in cystic fibrosis may be age-dependent.

Clinical and experimental immunology·2006
Same journal

The dendritic cell identity crisis: why conflicting classifications demand a consensus framework?

Immunology letters·2026
Same journal

The malignancy within: what cancer teaches us about human bonds.

Immunology letters·2026
Same journal

Progranulin enhances complement component 5a-primed neutrophil activation in antineutrophil cytoplasmic antibody-associated vasculitis.

Immunology letters·2026
Same journal

The subsets of circulating follicular helper T cells play an important role in the pathogenesis of Autoimmune thyroid diseases.

Immunology letters·2026
Same journal

Could bradykinin pathway inhibition change the course of severe hantavirus disease?

Immunology letters·2026
Same journal

Lactate-related diagnostic signature in rheumatoid arthritis: WGCNA and LASSO analysis with experimental validation.

Immunology letters·2026
See all related articles

Mannan-binding protein (MBP) levels were similar in pre-eclampsia patients and blood donors. However, recurrent pre-eclampsia cases showed significantly lower MBP levels compared to first-time occurrences, requiring further study.

Area of Science:

  • Immunology
  • Reproductive Medicine
  • Clinical Chemistry

Background:

  • Pre-eclampsia is a serious pregnancy complication.
  • Mannan-binding protein (MBP) plays a role in the innate immune system.
  • MBP levels may be altered in pregnancy disorders.

Purpose of the Study:

  • To investigate Mannan-binding protein (MBP) levels in patients with proteinuric pre-eclampsia.
  • To compare MBP levels between pre-eclamptic patients, their partners, and healthy blood donors.
  • To explore potential differences in MBP levels associated with recurrent vs. primiparous pre-eclampsia.

Main Methods:

  • Serum samples were collected from 95 patients with proteinuric pre-eclampsia and 76 of their husbands.
  • MBP levels were quantified in patient sera, partner sera, and compared to 352 healthy blood donor sera.

Related Experiment Videos

  • Data were analyzed to identify significant differences in MBP levels based on pre-eclampsia history.

    • Main Results:

    • No significant difference in MBP levels was observed between pre-eclamptic patients and healthy blood donors.
    • Significantly lower MBP levels were found in couples with recurrent pre-eclampsia compared to couples with first-time pre-eclampsia.
    • The finding regarding recurrent pre-eclampsia was exploratory and requires independent validation.

    Conclusions:

    • MBP levels do not appear to be significantly altered in patients with proteinuric pre-eclampsia compared to the general population.
    • Lower MBP levels in couples with recurrent pre-eclampsia suggest a potential role for MBP in pre-eclampsia recurrence.
    • Further research with larger cohorts is necessary to confirm the association between MBP levels and recurrent pre-eclampsia.