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Updated: Aug 13, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
[Forced stability study of ipriflavone]
V M Magdolna1, S Kálmán, R Imola
1Chinoin Gyógyszer-és Vegyészeti Termékek Gyára Rt., Kémiai Kutatási Osztály.
Abstract:
Forced stability study of ipriflavone has been conducted on solid state and in solution using different chromatographic techniques (TLC, HPLC, LC-TSP-MS) for measurement and identification. In solid state effect of high temperature, UV irradiation and that of artificial daylight were studied. In solution susceptibility to hydrolysis and oxidative ability were investigated. It was found that ipriflavone is stable in solid form at high temperature and against UV and daylight irradiation. In solution at high pH (pH > or = 9) ipriflavone is hydrolized and (2-hydroxy-4-isopropoxy-phenyl)benzyl-ketone develops as the main degradation product. Using hydrogen-peroxide or alpha,alpha'-asoisobutyronitrile ipriflavone can be oxidized, developing 2,3-dihydro-2,3-oxo-ipriflavone.
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