Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcriptional repression in development

S Gray1, M Levine

  • 1Department of Biology, University of California, San Diego, La Jolla 92093-0347, USA.

Current Opinion in Cell Biology
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different core promoters possess distinct regulatory activities in the Drosophila embryo.

Genes & development·1998
Same author

Rush to judgment? Child protective services and allegations of sexual abuse.

The American journal of orthopsychiatry·1998
Same author

In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats.

The Journal of pharmacology and experimental therapeutics·1998
Same author

Pulmonary toxicity of high-dose chemotherapy for breast cancer: a non-invasive approach to diagnosis and treatment.

Bone marrow transplantation·1998
Same author

Ascorbate recycling in human neutrophils: induction by bacteria.

Proceedings of the National Academy of Sciences of the United States of America·1998
Same author

The occurrence of subsequent malignancy in patients presenting with deep vein thrombosis: results from a historical cohort study.

Thrombosis and haemostasis·1998
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
Same journal

Substrate selectivity as a paradigm shift in mTORC1 signaling.

Current opinion in cell biology·2026
See all related articles

Transcriptional repression is crucial for cell-specific gene expression during embryogenesis. Studies reveal two types of repressors: short-range, allowing enhancer autonomy, and long-range, silencing multiple enhancers.

Area of Science:

  • Developmental Biology
  • Gene Regulation

Background:

  • Transcriptional repression plays a key role in establishing cell-type specific gene expression patterns during embryogenesis.
  • Recent research highlights the importance of transcriptional repression, comparable to activation, in developmental processes.

Purpose of the Study:

  • To categorize transcriptional repressors based on their mode of action during embryogenesis.
  • To differentiate between short-range and long-range repressors and their effects on gene expression.

Main Methods:

  • Analysis of recent studies in Drosophila melanogaster.
  • Categorization of transcriptional repressors based on functional assays and genetic screens (inferred).

Main Results:

  • Identification of two distinct categories of transcriptional repressors: short-range and long-range.

Related Experiment Videos

  • Short-range repressors allow for enhancer autonomy within modular promoters.
  • Long-range repressors act in a dominant manner to silence multiple enhancers simultaneously.

    • Conclusions:

    • Transcriptional repression is a fundamental mechanism in embryonic gene regulation.
    • The distinction between short-range and long-range repressors provides a framework for understanding complex gene expression patterns.
    • This classification aids in dissecting the regulatory logic governing cell fate determination.