The role of adrenoceptor-mediated signals in the modulation of lymphocyte function

Adrenoceptors are heterotrimeric glycoproteins that bind specific endogenous ligands, such as the sympathetic neurotransmitter norepinephrine and the neurohormone epinephrine. Ligand binding to an adrenoceptor expressed on the cell surface initiates a cascade of biochemical and molecular responses inside the cell that lead to a change in cellular activity. Initially, the stimulation of an adrenoceptor directly activates G proteins that stimulate enzymes to induce the production of second messengers. The cascade continues as the second messengers activate serine/threonine protein kinases, resulting in either an inhibition or enhancement of cellular activity. The resulting changes in cellular activity are mediated by changes in gene expression that are induced by the phosphorylation of specific transcription factors. Adrenoceptor subtypes are expressed by both T and B lymphocytes. The aim of this review is to summarize and discuss the results from the many studies that have examined the role of adrenoceptor-mediated intracellular signals in the modulation of lymphocyte function. Another aim of this review is to discuss how these studies have advanced our understanding of the mechanisms by which the sympathetic nervous system transmits information to both T and B lymphocytes to maintain immune homeostasis.