Chemical- and toxin-induced hepatotoxicity

Hepatic injury due to chemicals or natural toxins may occur from occupational, household, or environmental exposure. The liver may dominate the syndrome of toxicity from such agents as carbon tetrachloride, poison mushrooms, and toxic alkaloids, or may be only one facet of more generalized toxicity. The entire histologic spectrum of injury, from fulminant acute disease to chronic vascular injury to hepatic neoplasia, is seen with agents in this category.