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Pain in multiple system atrophy

F Tison1, G K Wenning, M A Volonte

  • 1Departement de Neurologie, Hopital Pellegrin, Bordeaux Cedex, France.

Journal of Neurology
|February 1, 1996
PubMed
Summary
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Pain affects nearly half of patients with multiple system atrophy (MSA), a common cause of atypical parkinsonism. This study details pain types and prevalence in MSA, finding it similar to Parkinson's disease but with different pain category distributions.

Area of Science:

  • Neurology
  • Neurodegenerative Diseases
  • Pain Medicine

Background:

  • Idiopathic Parkinson's disease (IPD) is known to cause pain.
  • Multiple system atrophy (MSA), the most frequent cause of atypical parkinsonism, has not been studied for pain.
  • Understanding pain in MSA is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate the prevalence and characteristics of pain in patients with clinically probable MSA.
  • To compare pain profiles in MSA with those reported in IPD.

Main Methods:

  • Retrospective analysis of medical records from 100 patients with probable MSA (82 striatonigral degeneration [SND] type, 18 olivopontocerebellar atrophy [OPCA] type).
  • Detailed review of patient histories to identify pain occurrence, classification, and relationship to disease onset and treatment.

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Main Results:

  • Pain was reported by 47% of MSA patients.
  • Common pain types included rheumatic (64%), sensory (28%), dystonic (21%), and levodopa-related (16%).
  • Pain was more prevalent in females and those with levodopa-induced dyskinesias; onset often preceded or coincided with disease diagnosis.

Conclusions:

  • Pain is a significant feature in nearly half of MSA patients, with a prevalence comparable to IPD.
  • The types of pain experienced in MSA differ from those typically seen in IPD.
  • Further research into pain mechanisms and management in MSA is warranted.