[The photolytical products of aqueous carboplatin solution]

Carboplatin, an abbreviation for 1, 1-cyclobutanedicarboxylatodiamine platinum (II), is the second generation platinum anticancer drug. The stability of its aqueous solution is of great importance to clinical effects. It has been known that the solution is relatively stable with t1/2 being about three months when kept in dark place, and unstable to light as shown by the rapid change in the UV spectrum. But, the photolytic products remain unidentified. As a knowledge of the products plays an important role in understanding the influence of photolysis of carboplatin on the clinical effects, we have recently studied the photolytical products of aqueous carboplatin solution upon 313 and 254 nm irradiation, and now report our results here.