Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How many signals does it take?

T V Venkatesh1, R Bodmer

  • 1Department of Biology, University of Michigan, Ann Arbor 48109, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The bHLH Protein Nulp1 is Essential for Femur Development Via Acting as a Cofactor in Wnt Signaling in Drosophila.

Current molecular medicine·2018
Same author

Evolutionary history and identification of conservation units in the giant otter, Pteronura brasiliensis.

Molecular phylogenetics and evolution·2011
Same author

Heart development in Drosophila and its relationship to vertebrates.

Trends in cardiovascular medicine·2011
Same author

Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster.

Developmental biology·2008
Same author

Integromics: challenges in data integration.

Genome biology·2002
Same author

The selector gene cut represses a neural cell fate that is specified independently of the Achaete-Scute-Complex and atonal.

Mechanisms of development·2001
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

Decapentaplegic (Dpp) protein, a Transforming Growth Factor-beta (TGF-beta) family member, signals from dorsal ectoderm to pattern the mesoderm primordium in Drosophila. This study clarifies molecular mechanisms in mesodermal subtype development.

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • Dorsal-ventral polarity and mesoderm formation in Drosophila are well-understood.
  • Molecular mechanisms patterning the mesoderm primordium into subtypes remain unclear.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying mesodermal subtype patterning.
  • To identify inductive signals from dorsal ectoderm involved in mesoderm subdivision.

Main Methods:

  • Analysis of genetic interactions and signaling pathways in Drosophila melanogaster.
  • Utilizing molecular and cellular techniques to study gene expression and protein function.

Main Results:

  • Evidence suggests an inductive signal from dorsal ectoderm is crucial for mesoderm patterning.

Related Experiment Videos

  • Decapentaplegic (Dpp), a bone morphogenetic protein, is identified as a key signaling factor.

    • Conclusions:

    • Dpp signaling plays a significant role in subdividing the mesoderm primordium.
    • This research sheds light on the molecular basis of mesodermal patterning in Drosophila development.