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[Early alterations in release of nitrogen monoxide by the retinal after experimental venous occlusion]
G Donati1, C J Pournaras, C Kalogeropoulos
1Clinique d'Ophtalmologie, HCUG.
Purpose:
We present hereby some results indicating that there is a significant decrease in the release of NO by the retina immediately after branch-venous occlusion (BVO).
Methods:
Using an NO microprobe we measured (NO) in the preretinal vitreous of miniature pigs before and two hours aRer bvo. Conventional and electronic microscopy were performed on the affected retina.
Results:
At the retinal surface (NO) was reduced to 25% of the previous value two hours after BVO, at the same time significative oedema of the inner retina was observed.
Conclusions:
Immediately after BVO there is a significative decrease in the amount of NO released by the affected retina, parallel to the first evidences of an oedema of the inner retinal layers.