[The repopulation and regranulation of tissue basophils at the site of acute inflammation]

Regularities of rat mast cells (MC) repopulation and regranulation in late reparative stage of inflammation compared to that in conditions approximating to MC natural renewal (after their osmiophilic elimination) and MC restoration after the inflammation caused during their absence were established on the model of E.coli induced acute infectious peritonitis. MC number in peritoneal fluid and mesenterium restores by 90th day in typical development of the inflammation, with peritoneal MC regranulation yielding to that in mesenterium and remaining unfinished by 120th day. MC repopulation in peritoneal fluid and mesenterium forestalls the one observed after the osmotic MC elimination. Inflammation, induced during MC absence retards peritoneal MC regranulation and promotes that of mesenterial ones. MC repopulation and regranulation on the site of inflammation combines their degranulation and high content of free histamine in peritoneal fluid and mesenterium.