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Related Experiment Videos

Does peri-operative guanethidine prevent reflex sympathetic dystrophy?

C Gschwind1, R Fricker, G Lacher

  • 1Department of Hand Surgery, Kantonsspital, Basel, Switzerland.

Journal of Hand Surgery (Edinburgh, Scotland)
|December 1, 1995
PubMed
Summary
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Peri-operative intravenous guanethidine blocks do not prevent reflex sympathetic dystrophy (RSD) after surgery. This study found no protective effect, challenging current clinical practices for post-operative pain management.

Area of Science:

  • Pain Management
  • Surgical Complications
  • Pharmacology

Background:

  • Intravenous guanethidine blocks are used for established reflex sympathetic dystrophy (RSD).
  • Some clinicians use peri-operative guanethidine to prevent post-operative dystrophy.
  • Evidence supporting this prophylactic use is lacking.

Purpose of the Study:

  • To investigate the efficacy of peri-operative intravenous guanethidine in preventing post-operative reflex sympathetic dystrophy (RSD).

Main Methods:

  • A prospective, randomized, double-blind study.
  • Conducted between 1992 and 1994.
  • Involved 71 patients undergoing fasciectomy for Dupuytren's disease.

Main Results:

Related Experiment Videos

  • Peri-operative administration of intravenous guanethidine did not prevent the development of post-operative RSD.
  • The study found no statistically significant protective effect.

    • Conclusions:

    • Peri-operative intravenous guanethidine is ineffective in preventing post-operative reflex sympathetic dystrophy (RSD).
    • Clinical protocols for preventing post-operative dystrophy may need re-evaluation.