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Decrease of fibronectin following repeated infusion of highly substituted hydroxyethyl starch

J Treib1, A Haass, G Pindur

  • 1Neurologische Klinik, Universitätskliniken des Saarlandes, Hornburg.

Infusionstherapie Und Transfusionsmedizin
|April 1, 1996
PubMed
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Hemodilution therapy significantly reduced fibronectin (Fn) levels in patients with cerebrovascular issues. This drug-induced decrease in Fn may indicate reticulo-endothelial system depression and has potential clinical relevance.

Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Fibronectin (Fn) is crucial for the innate immune system, mediating particle and pathogen binding to phagocytic cells of the reticulo-endothelial system (RES).
  • Understanding Fn's role is vital for comprehending immune responses and potential therapeutic interventions.

Purpose of the Study:

  • To investigate the impact of a 10-day hemodilution therapy on human fibronectin (Fn) concentrations.
  • To assess the dose-dependent effects of hydroxyethyl starch (HES) on Fn levels.

Main Methods:

  • A randomized study involving 12 patients with cerebrovascular perfusion disturbances.
  • Treatment with either 10% HES 200/0.62 or 6% HES 200/0.62 for 10 days.
  • Fibronectin concentration was measured using simple radial immunodiffusion.

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Main Results:

  • A significant, dose-dependent decrease in Fn concentration was observed in all patients (p < 0.01), exceeding the expected dilution effect.
  • 10% HES 200/0.62 resulted in a 62.2% Fn reduction (26.6 to 10.0 mg/dl).
  • 6% HES 200/0.62 led to a 41.1% Fn decrease (25.5 to 15.0 mg/dl).

Conclusions:

  • The observed reduction in Fn suggests a potential depression of the reticulo-endothelial system (RES).
  • Fibronectin's roles extend beyond defense to embryogenesis, wound healing, and hemostasis.
  • Drug-induced reduction of Fn may hold significant clinical implications.